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Risk Modification based on Sonographic Findings and Multiple-Marker Screening

 

Maternal Age (Yr.)

Age-related risk of trisomy 18

Unmodified risk Modified Risk
Choroid Plexus Cyst* Isolated Choroid Plexus Cyst** Isolated Choroid Plexus Cyst & Normal MMS***
20 1/4576 1/153 1/725 1/1804
21 1/4514 1/151 1/715 1/1779
22 1/4435 1/148 1/703 1/1749
23 1/4333 1/145 1/687 1/1708
24 1/4204 1/141 1/666 1/1658
25 1/4045 1/135 1/641 1/1595
26 1/3850 1/129 1/610 1/1518
27 1/3619 1/121 1/573 1/1427
28 1/3351 1/113 1/531 1/1362
29 1/3053 1/102 1/483 1/1203
30 1/2724 1/92 1/432 1/1074
31 1/2385 1/80 1/378 1/940
32 1/2046 1/69 1/324 1/806
33 1/1721 1/58 1/273 1/679
34 1/1420 1/48 1/225 1/560
35 1/1152 1/39 1/183 1/454
36 1/921 1/32 1/146 1/363
37 1/727 1/25 1/115 1/287
38 1/567 1/20 1/92 1/223
39 1/439 1/16 1/70 1/173
40 1/338 1/12 1/54 1/133
41 1/258 1/10 1/42 1/102
42 1/197 1/8 1/32 1/78
43 1/149 1/6 1/24 1/59
44 1/113 1/5 1/18 1/45
45 1/85 1/4 1/14 1/34

From: Gratton RJ, Hogge WA, Aston CE. Choroid plexus cysts and trisomy 18: Risk modification based on maternal age and multiple-marker screening. Am J Obstet Gynecol 175:1493-7, 1996 (Unmodified risk estimates are adapted from Snijders RJM, Holzgreve W, Cuckle H, Nicolaides KH. Maternal age specific risk for trisomies at 9-14 weeks gestation. Prenatal Diagn 14:543-52, 1994) MMS= multiple-marker screening

* Age-related risk of trisomy 18 in fetuses with choroid plexus cyst , with or without other anomalies

**Age-related risk of trisomy 18 in fetuses with isolated choroid plexus cyst

***Age-related risk of trisomy 18 in fetuses with isolated choroid plexus cyst and normal multiple-marker screen results

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Ultrasound Educational Press     Go Top
Peter W. Callen, M.D.
Professor of Radiology, Obstetrics, Gynecology and Reproductive Science
University of California Medical Center, San Francisco, California

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